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이미화 ( ) - 진주보건대학 임상병리과
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Abstract
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Several polymorphisms of the .8 fibrinogen gene including MnII polymorphism in the promotor region of the gene and Bc1I polymorphism in its downstream region have been investigated in relation to plasma fibrinogen levels.
For this study, the blood samples for DNA were collected from 109 healthy Koreans who have no relationship by blood(67 males and 42 females) in due consideration of some other factors such as gender, age, and smoking status. Two polymorphisms of the Q fibrinogen gene that consist of MnII, and BcII restriction fragment length polymorphisms (RFLPs) were investigated to examine the associations between RFLPs and plasma fibrinogen levels.
The results were as follows:
1. Genotype MiMi and MiMz in MnII RFLPs from 70(64.2%) and 39(35.8%) persons respectively.
Among 95 control subjects, genotype BiBi and BIB_ in Bc1I RFLPs were shown in 70(73.7%) and 25(26.3%) persons respectively.
2. The significant associations between Mn11 RFLPs( MiM2) and plasma fibrinogen were ascertained in both aged people(_ 50 years) and smokers, whereas the associations between BcII RFLPs and plasma fibrinogen were absent showing no connection with age or smoking status.
3. Plasma fibrinogen concentrations were significantly higher in the old ages(_ 50 years) than in the younger ages(S 49 years) in male, and also higher in smokers than in nonsmokers.
In conclusion, genetic polymorphisms( MiM2) of the Q fibrinogen gene are associated and increased with plasma fibrinogen levels, especially in aged people and in smokers. These findings suggest that variation at the fibrinogen gene locus may contribute to the differences in plasma fibrinogen -level.
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KeyWords
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원문 및 링크아웃 정보
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등재저널 정보
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